Fake anti-malarials: start with the facts.
Identifieur interne : 000202 ( Main/Exploration ); précédent : 000201; suivant : 000203Fake anti-malarials: start with the facts.
Auteurs : Harparkash Kaur [Royaume-Uni] ; Si N Clarke [Royaume-Uni] ; Mirza Lalani [Royaume-Uni] ; Souly Phanouvong [États-Unis] ; Philippe Guérin [Royaume-Uni] ; Andrew Mcloughlin [Suisse] ; Benjamin K. Wilson [États-Unis] ; Michael Deats [Suisse] ; Aline Plançon [France] ; Heidi Hopkins [Royaume-Uni] ; Debora Miranda [Royaume-Uni] ; David Schellenberg [Royaume-Uni]Source :
- Malaria journal [ 1475-2875 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- normes : Antipaludiques, Artémisinines.
- traitement médicamenteux : Paludisme.
- usage thérapeutique : Antipaludiques, Artémisinines.
- Association de médicaments, Humains.
English descriptors
- KwdEn :
- MESH :
- chemical , standards : Antimalarials, Artemisinins.
- chemical , therapeutic use : Antimalarials, Artemisinins.
- drug therapy : Malaria.
- Drug Therapy, Combination, Humans.
Abstract
This meeting report presents the key findings and discussion points of a 1-day meeting entitled 'Fake anti-malarials: start with the facts' held on 28th May 2015, in Geneva, Switzerland, to disseminate the findings of the artemisinin combination therapy consortium's drug quality programme. The teams purchased over 10,000 samples, using representative sampling approaches, from six malaria endemic countries: Equatorial Guinea (Bioko Island), Cambodia, Ghana, Nigeria, Rwanda and Tanzania. Laboratory analyses of these samples showed that falsified anti-malarials (<8 %) were found in just two of the countries, whilst substandard artemisinin-based combinations were present in all six countries and, artemisinin-based monotherapy tablets are still available in some places despite the fact that the WHO has urged regulatory authorities in malaria-endemic countries to take measures to halt the production and marketing of these oral monotherapies since 2007. This report summarizes the presentations that reviewed the public health impact of falsified and substandard drugs, sampling strategies, techniques for drug quality analysis, approaches to strengthen health systems capacity for the surveillance of drug quality, and the ensuing discussion points from the dissemination meeting.
DOI: 10.1186/s12936-016-1096-x
PubMed: 26873700
Affiliations:
- France, Royaume-Uni, Suisse, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Maryland, Oxfordshire, Rhône-Alpes, Washington (État)
- Lyon, Oxford
- Université d'Oxford
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Le document en format XML
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Philippe.Guerin@wwarn.org.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Worldwide Antimalarial Resistance Network (WWARN), University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Mcloughlin, Andrew" sort="Mcloughlin, Andrew" uniqKey="Mcloughlin A" first="Andrew" last="Mcloughlin">Andrew Mcloughlin</name><affiliation wicri:level="1"><nlm:affiliation>The Global Fund to Fight Aids, Tuberculosis and Malaria, Geneva, Switzerland. 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Heidi.Hopkins@lshtm.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London, WC1E 7HT</wicri:regionArea><wicri:noRegion>WC1E 7HT</wicri:noRegion></affiliation></author><author><name sortKey="Miranda, Debora" sort="Miranda, Debora" uniqKey="Miranda D" first="Debora" last="Miranda">Debora Miranda</name><affiliation wicri:level="1"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. Debora.Miranda@lshtm.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London, WC1E 7HT</wicri:regionArea><wicri:noRegion>WC1E 7HT</wicri:noRegion></affiliation></author><author><name sortKey="Schellenberg, David" sort="Schellenberg, David" uniqKey="Schellenberg D" first="David" last="Schellenberg">David Schellenberg</name><affiliation wicri:level="1"><nlm:affiliation>London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK. David.Schellenberg@lshtm.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine, London, WC1E 7HT</wicri:regionArea><wicri:noRegion>WC1E 7HT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Malaria journal</title><idno type="eISSN">1475-2875</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimalarials (standards)</term><term>Antimalarials (therapeutic use)</term><term>Artemisinins (standards)</term><term>Artemisinins (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Malaria (drug therapy)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antipaludiques (normes)</term><term>Antipaludiques (usage thérapeutique)</term><term>Artémisinines (normes)</term><term>Artémisinines (usage thérapeutique)</term><term>Association de médicaments</term><term>Humains</term><term>Paludisme (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="standards" xml:lang="en"><term>Antimalarials</term><term>Artemisinins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term><term>Artemisinins</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Antipaludiques</term><term>Artémisinines</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term><term>Artémisinines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Therapy, Combination</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Association de médicaments</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This meeting report presents the key findings and discussion points of a 1-day meeting entitled 'Fake anti-malarials: start with the facts' held on 28th May 2015, in Geneva, Switzerland, to disseminate the findings of the artemisinin combination therapy consortium's drug quality programme. The teams purchased over 10,000 samples, using representative sampling approaches, from six malaria endemic countries: Equatorial Guinea (Bioko Island), Cambodia, Ghana, Nigeria, Rwanda and Tanzania. Laboratory analyses of these samples showed that falsified anti-malarials (<8 %) were found in just two of the countries, whilst substandard artemisinin-based combinations were present in all six countries and, artemisinin-based monotherapy tablets are still available in some places despite the fact that the WHO has urged regulatory authorities in malaria-endemic countries to take measures to halt the production and marketing of these oral monotherapies since 2007. This report summarizes the presentations that reviewed the public health impact of falsified and substandard drugs, sampling strategies, techniques for drug quality analysis, approaches to strengthen health systems capacity for the surveillance of drug quality, and the ensuing discussion points from the dissemination meeting.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Maryland</li><li>Oxfordshire</li><li>Rhône-Alpes</li><li>Washington (État)</li></region><settlement><li>Lyon</li><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Kaur, Harparkash" sort="Kaur, Harparkash" uniqKey="Kaur H" first="Harparkash" last="Kaur">Harparkash Kaur</name></noRegion><name sortKey="Clarke, Si N" sort="Clarke, Si N" uniqKey="Clarke S" first="Si N" last="Clarke">Si N Clarke</name><name sortKey="Guerin, Philippe" sort="Guerin, Philippe" uniqKey="Guerin P" first="Philippe" last="Guérin">Philippe Guérin</name><name sortKey="Hopkins, Heidi" sort="Hopkins, Heidi" uniqKey="Hopkins H" first="Heidi" last="Hopkins">Heidi Hopkins</name><name sortKey="Lalani, Mirza" sort="Lalani, Mirza" uniqKey="Lalani M" first="Mirza" last="Lalani">Mirza Lalani</name><name sortKey="Miranda, Debora" sort="Miranda, Debora" uniqKey="Miranda D" first="Debora" last="Miranda">Debora Miranda</name><name sortKey="Schellenberg, David" sort="Schellenberg, David" uniqKey="Schellenberg D" first="David" last="Schellenberg">David Schellenberg</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Phanouvong, Souly" sort="Phanouvong, Souly" uniqKey="Phanouvong S" first="Souly" last="Phanouvong">Souly Phanouvong</name></region><name sortKey="Wilson, Benjamin K" sort="Wilson, Benjamin K" uniqKey="Wilson B" first="Benjamin K" last="Wilson">Benjamin K. Wilson</name></country><country name="Suisse"><noRegion><name sortKey="Mcloughlin, Andrew" sort="Mcloughlin, Andrew" uniqKey="Mcloughlin A" first="Andrew" last="Mcloughlin">Andrew Mcloughlin</name></noRegion><name sortKey="Deats, Michael" sort="Deats, Michael" uniqKey="Deats M" first="Michael" last="Deats">Michael Deats</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Plancon, Aline" sort="Plancon, Aline" uniqKey="Plancon A" first="Aline" last="Plançon">Aline Plançon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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